FZD8

Across TCGA cell cohorts, FZD8 mutation is significantly associated with the RNA expression of many other genes, with 133 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FZD8-associated genes across cancer lineages are TSPAN19, C9, and HAO2. Each is linked with FZD8 in more than 1 cancer types. Because this analysis shows association rather than direction, both FZD8-to-partner and partner-to-FZD8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TSPAN19 grouped by FZD8-low versus FZD8-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FZD8→partner) and Y-score (partner→FZD8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TSPAN19 →	+0.284	+3.968	<.001	.002	3	2
BLOOD_Leukemia	C9 →	+1.335	+3.544	<.001	.008	3	1
BLOOD_Leukemia	HAO2 →	+0.035	+3.234	.001	.008	3	1
BLOOD_Leukemia	FLG2 →	+0.117	+4.007	<.001	.002	3	1
BLOOD_Leukemia	CYP39A1 →	+0.111	+4.091	.005	.002	3	1
BLOOD_Leukemia	CPXCR1 →	+0.072	+3.623	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 133 associations by consensus.

TSPAN19 by FZD8 expression — BLOOD_Leukemia

Explore this box plot interactively →