FZD7

Across TCGA patient cohorts, FZD7 mutation is significantly associated with the total protein of many other genes, with 57 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FZD7-associated genes across cancer lineages are Caspase-7-cleavedD198, MIG-6, and C-Raf. Each is linked with FZD7 in more than 2 cancer types. Because this analysis shows association rather than direction, both FZD7-to-partner and partner-to-FZD7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by FZD7-low versus FZD7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FZD7→partner) and Y-score (partner→FZD7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.369	+1.300	.039	.034	3	3
COAD	MIG-6 →	+0.118	+2.820	.007	.035	3	2
UCEC	C-Raf →	+0.153	+1.874	<.001	.002	3	2
UCEC	JNK_pT183_Y185 →	-0.198	-2.070	<.001	.001	3	2
UCEC	Notch1 →	+0.137	+1.861	.001	.004	3	2
UCEC	PCNA →	+0.177	+1.925	.006	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 57 associations by consensus.

Caspase-7-cleavedD198 by FZD7 expression — UCEC

Explore this box plot interactively →