FZD7

Across TCGA cell cohorts, FZD7 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,959 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible FZD7-associated GO terms across cancer lineages are Negative regulation of cardiac muscle cell differentiation, Gliogenesis, and Regulation of actin filament bundle assembly. Each is linked with FZD7 in more than 10 cancer types. Because this analysis shows association rather than direction, both FZD7-to-partner and partner-to-FZD7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of cardiac muscle cell differentiation grouped by FZD7-low versus FZD7-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FZD7→partner) and Y-score (partner→FZD7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Negative regulation of cardiac muscle cell differentiation →	+0.277	+1.419	.003	.002	3	11
STOMACH	Gliogenesis →	+0.066	+1.947	<.001	.001	3	11
BONE	Regulation of actin filament bundle assembly →	+0.087	+1.271	.008	.009	3	11
BREAST	Negative regulation of myoblast fusion →	+0.124	+1.883	<.001	<.001	3	10
PANCREAS	Positive regulation of cellular response to transforming growth factor beta stimulus →	+0.089	+1.580	<.001	<.001	3	10
PANCREAS	Positive regulation of transforming growth factor beta receptor signaling pathway →	+0.089	+1.580	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,959 associations by consensus.

Negative regulation of cardiac muscle cell differentiation by FZD7 expression — SOFT_TISSUE

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