FZD7

Across TCGA cell cohorts, FZD7 mutation is significantly associated with the RNA expression of many other genes, with 19 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FZD7-associated genes across cancer lineages are AVP, REG1B, and GJA10. Each is linked with FZD7 in more than 1 cancer types. Because this analysis shows association rather than direction, both FZD7-to-partner and partner-to-FZD7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AVP grouped by FZD7-low versus FZD7-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FZD7→partner) and Y-score (partner→FZD7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	AVP →	+0.031	+5.209	<.001	.005	3	2
BREAST	REG1B →	+1.039	+5.169	<.001	.005	3	2
OESOPHAGUS	GJA10 →	+0.035	+4.857	<.001	<.001	3	1
OESOPHAGUS	SLC22A10 →	+0.038	+4.017	<.001	.007	3	1
OESOPHAGUS	DCDC2C →	+0.107	+4.392	<.001	.003	3	1
SOFT_TISSUE	DPRX →	+0.038	+5.369	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

AVP by FZD7 expression — BLOOD_Lymphoma

Explore this box plot interactively →