FZD6

Across TCGA pan-cancer cohorts, FZD6 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated FZD6 data layer compared with 20 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher FZD6 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated FZD6 expression acts as an unfavorable survival marker.

HNSC, CCRCC, and PDAC are the cancer types where FZD6 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	IV	0.580	0.892	.001	23	view →
CCRCC	DFS	Median	II,III,IV	0.362	1.000	.005	12	view →
PDAC	OS	Median	IV	0.472	0.951	.010	9	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

FZD6–HNSC (DFS)

Open the HNSC breakdown →