FZD6

Across TCGA patient cohorts, FZD6 mutation is significantly associated with the RNA expression of many other genes, with 4,718 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FZD6-associated genes across cancer lineages are DSCR4-IT1, RNU6-893P, and TBC1D3J. Each is linked with FZD6 in more than 2 cancer types. Because this analysis shows association rather than direction, both FZD6-to-partner and partner-to-FZD6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DSCR4-IT1 grouped by FZD6-low versus FZD6-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FZD6→partner) and Y-score (partner→FZD6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	DSCR4-IT1 →	+0.201	+4.812	.004	.006	3	3
CESC	RNU6-893P →	+0.422	+4.193	.003	.009	3	3
BLCA	TBC1D3J →	+0.240	+3.574	<.001	.006	3	2
CESC	MAGEA9 →	+0.185	+5.127	<.001	.001	3	2
CESC	PRAMEF14 →	+0.094	+4.669	<.001	.007	3	2
CESC	KRTAP2-2 →	+0.965	+5.269	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,718 associations by consensus.

DSCR4-IT1 by FZD6 expression — CESC

Explore this box plot interactively →