FZD6

Across TCGA patient cohorts, FZD6 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FZD6-associated genes across cancer lineages are ASNS, Bak, and Caspase-7-cleavedD198. Each is linked with FZD6 in more than 1 cancer types. Because this analysis shows association rather than direction, both FZD6-to-partner and partner-to-FZD6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by FZD6-low versus FZD6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FZD6→partner) and Y-score (partner→FZD6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.389	+2.392	<.001	<.001	3	2
UCEC	Bak →	+0.158	+1.502	.032	.025	3	2
UCEC	Caspase-7-cleavedD198 →	+0.489	+2.412	.005	<.001	3	2
UCEC	4E-BP1 →	+0.285	+3.087	<.001	<.001	3	2
UCEC	C-Raf →	+0.123	+1.362	.003	.034	3	2
UCEC	14-3-3_beta →	-0.059	-1.880	.046	.014	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

ASNS by FZD6 expression — UCEC

Explore this box plot interactively →