FZD6

Across TCGA cell cohorts, FZD6 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,823 significant associations in total. BONE shows the largest number of these associations.

The most reproducible FZD6-associated GO terms across cancer lineages are Regulation of apoptotic signaling pathway, Positive regulation of viral process, and Negative regulation of protein modification process. Each is linked with FZD6 in more than 10 cancer types. Because this analysis shows association rather than direction, both FZD6-to-partner and partner-to-FZD6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of apoptotic signaling pathway grouped by FZD6-low versus FZD6-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FZD6→partner) and Y-score (partner→FZD6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of apoptotic signaling pathway →	+0.078	+1.940	<.001	<.001	3	11
STOMACH	Positive regulation of viral process →	+0.086	+1.921	.001	.001	3	11
OVARY	Negative regulation of protein modification process →	+0.048	+1.910	<.001	<.001	3	11
BONE	Regulation of intracellular transport →	+0.072	+2.792	<.001	<.001	3	11
BONE	Response to endoplasmic reticulum stress →	+0.075	+2.068	.003	.008	3	11
BONE	Amyloid-beta clearance by transcytosis →	+0.178	+1.620	<.001	.003	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,823 associations by consensus.

Regulation of apoptotic signaling pathway by FZD6 expression — BONE

Explore this box plot interactively →