FZD6

Across TCGA cell cohorts, FZD6 mutation is significantly associated with the RNA expression of many other genes, with 26 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible FZD6-associated genes across cancer lineages are SULT6B1, GPR171, and OLIG3. Each is linked with FZD6 in more than 1 cancer types. Because this analysis shows association rather than direction, both FZD6-to-partner and partner-to-FZD6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SULT6B1 grouped by FZD6-low versus FZD6-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FZD6→partner) and Y-score (partner→FZD6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SULT6B1 →	+0.021	+2.977	<.001	.006	3	1
LARGE_INTESTINE	GPR171 →	+0.011	+3.009	.003	.001	3	1
LARGE_INTESTINE	OLIG3 →	+0.021	+2.832	<.001	.002	3	1
LARGE_INTESTINE	SERPINA11 →	+0.052	+2.518	<.001	.006	3	1
LUNG_NSCLC_LUAD	OR7G3 →	+0.026	+4.681	<.001	.003	3	1
LUNG_NSCLC_LUAD	OBP2B →	+0.053	+3.544	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

SULT6B1 by FZD6 expression — LARGE_INTESTINE

Explore this box plot interactively →