FZD5

Across TCGA patient cohorts, FZD5 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FZD5-associated genes across cancer lineages are VHL, ATM, and EGFR_pY1068. Each is linked with FZD5 in more than 1 cancer types. Because this analysis shows association rather than direction, both FZD5-to-partner and partner-to-FZD5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VHL grouped by FZD5-low versus FZD5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FZD5→partner) and Y-score (partner→FZD5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	VHL →	-0.746	-1.807	.003	.025	3	2
UCEC	ATM →	-0.500	-3.700	.003	.001	3	2
UCEC	EGFR_pY1068 →	-0.210	-2.999	.026	.035	3	1
UCEC	eIF4E →	+0.181	+2.169	.022	.003	3	1
UCEC	eIF4G →	+0.259	+1.415	.026	.046	3	1
UCEC	A-Raf_pS299 →	-0.129	-1.807	.003	.025	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

VHL by FZD5 expression — UCEC

Explore this box plot interactively →