FZD4

Across TCGA patient cohorts, FZD4 mutation is significantly associated with the total protein of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FZD4-associated genes across cancer lineages are p38-MAPK_pT180_Y182, Src_pY527, and Caspase-7-cleavedD198. Each is linked with FZD4 in more than 1 cancer types. Because this analysis shows association rather than direction, both FZD4-to-partner and partner-to-FZD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p38-MAPK_pT180_Y182 grouped by FZD4-low versus FZD4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FZD4→partner) and Y-score (partner→FZD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p38-MAPK_pT180_Y182 →	-0.494	-3.087	.001	<.001	3	2
UCEC	Src_pY527 →	-0.299	-2.321	.041	.033	3	2
UCEC	Caspase-7-cleavedD198 →	+0.540	+1.505	.007	.034	3	2
UCEC	eEF2 →	+0.284	+2.459	.019	.018	3	1
UCEC	eIF4E →	+0.203	+2.713	.004	.003	3	1
UCEC	eIF4G →	+0.272	+2.459	.010	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

p38-MAPK_pT180_Y182 by FZD4 expression — UCEC

Explore this box plot interactively →