FZD4-DT

Across TCGA pan-cancer cohorts, FZD4-DT RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated FZD4-DT data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher FZD4-DT RNA is associated with better overall survival. In most high-consensus cancer types, elevated FZD4-DT expression acts as an unfavorable survival marker, although some lineages such as KIRC and UCS show a favorable association.

KIRC, UCS, and MESO are the cancer types where FZD4-DT RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.724	0.543	<.001	113	view →
UCS	OS	Tertile	II,III,IV	0.825	0.269	<.001	64	view →
MESO	OS	Median	III,IV	0.794	0.291	.001	50	view →
LGG	OS	Median	All	0.749	0.868	<.001	36	view →
CESC	DFS	Quartile	All	0.754	0.903	.001	36	view →
BRCA	DFS	Tertile	III,IV	0.873	0.702	.002	35	view →
BLCA	OS	Median	III,IV	0.323	0.572	.004	32	view →
SKCM	DFS	Tertile	IV	0.126	0.706	.001	24	view →
OV	OS	Median	II,III,IV	0.743	0.640	.007	22	view →
ESCA	DFS	Tertile	IV	0.226	0.704	.024	12	view →
LAML	DFS	Tertile	All	0.247	0.550	.015	12	view →
ACC	DFS	Quartile	II,III,IV	0.244	0.664	.023	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

FZD4-DT–KIRC (OS)

Open the KIRC breakdown →