FZD2

Across TCGA patient cohorts, FZD2 mutation is significantly associated with the RNA expression of many other genes, with 3,201 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FZD2-associated genes across cancer lineages are PNP, ATP5F1A, and H2AZ1. Each is linked with FZD2 in more than 3 cancer types. Because this analysis shows association rather than direction, both FZD2-to-partner and partner-to-FZD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PNP grouped by FZD2-low versus FZD2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FZD2→partner) and Y-score (partner→FZD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PNP →	+0.522	+2.923	.002	<.001	3	3
COAD	ATP5F1A →	+0.631	+3.362	<.001	.005	3	3
STAD	H2AZ1 →	+0.578	+3.182	.003	.009	3	3
BLCA	RNU6-1138P →	+0.657	+5.320	<.001	.001	3	3
UCEC	TRIM36 →	+1.069	+3.000	<.001	<.001	3	3
UCEC	HSPA4L →	+0.748	+2.606	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,201 associations by consensus.

PNP by FZD2 expression — UCEC

Explore this box plot interactively →