FZD2

Across TCGA patient cohorts, FZD2 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FZD2-associated genes across cancer lineages are 14-3-3_beta, Akt_pT308, and 4E-BP1. Each is linked with FZD2 in more than 2 cancer types. Because this analysis shows association rather than direction, both FZD2-to-partner and partner-to-FZD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by FZD2-low versus FZD2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FZD2→partner) and Y-score (partner→FZD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	14-3-3_beta →	-0.203	-3.144	.044	.019	3	3
UCEC	Akt_pT308 →	+0.587	+2.584	.009	.010	3	3
UCEC	4E-BP1 →	+0.340	+2.321	<.001	.001	3	3
COAD	ASNS →	+0.609	+3.178	.001	.010	3	2
COAD	Cyclin-B1 →	+0.558	+2.824	.037	.034	3	2
UCEC	EGFR_pY1068 →	-0.253	-1.807	.005	.025	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

14-3-3_beta by FZD2 expression — COAD

Explore this box plot interactively →