FZD2

Across TCGA cell cohorts, FZD2 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,567 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible FZD2-associated GO terms across cancer lineages are Negative regulation of endodermal cell differentiation, Actin filament depolymerization, and Positive regulation of focal adhesion assembly. Each is linked with FZD2 in more than 13 cancer types. Because this analysis shows association rather than direction, both FZD2-to-partner and partner-to-FZD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of endodermal cell differentiation grouped by FZD2-low versus FZD2-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FZD2→partner) and Y-score (partner→FZD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Negative regulation of endodermal cell differentiation →	+1.773	+2.854	<.001	<.001	3	14
LUNG_NSCLC_LUSC	Actin filament depolymerization →	+0.214	+1.957	.003	.006	3	14
LIVER	Positive regulation of focal adhesion assembly →	+0.113	+3.313	.004	<.001	3	14
STOMACH	Regulation of actomyosin structure organization →	+0.090	+2.175	.002	.002	3	13
LUNG_NSCLC_LUSC	Peptidyl-lysine oxidation →	+1.627	+2.211	<.001	.004	3	13
URINARY_TRACT	Protein depolymerization →	+0.117	+1.641	.005	.006	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,567 associations by consensus.

Negative regulation of endodermal cell differentiation by FZD2 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →