FZD2

Across TCGA cell cohorts, FZD2 mutation is significantly associated with the RNA expression of many other genes, with 66 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible FZD2-associated genes across cancer lineages are ARGFX, GPR101, and C10orf53. Each is linked with FZD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both FZD2-to-partner and partner-to-FZD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ARGFX grouped by FZD2-low versus FZD2-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FZD2→partner) and Y-score (partner→FZD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	ARGFX →	+0.083	+5.357	<.001	.003	3	2
UPPER_AERODIGESTIVE_TRACT	GPR101 →	+0.106	+4.736	<.001	.009	3	2
UPPER_AERODIGESTIVE_TRACT	C10orf53 →	+0.020	+5.357	<.001	.003	3	2
LARGE_INTESTINE	SIGLEC8 →	+0.013	+3.930	<.001	.003	3	1
LARGE_INTESTINE	MYH8 →	+0.098	+3.920	<.001	.005	3	1
LARGE_INTESTINE	COX6A2 →	+0.082	+4.437	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 66 associations by consensus.

ARGFX by FZD2 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →