FYCO1

Across TCGA patient cohorts, FYCO1 mutation is significantly associated with the total protein of many other genes, with 59 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FYCO1-associated genes across cancer lineages are ATM, ASNS, and eEF2. Each is linked with FYCO1 in more than 3 cancer types. Because this analysis shows association rather than direction, both FYCO1-to-partner and partner-to-FYCO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by FYCO1-low versus FYCO1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FYCO1→partner) and Y-score (partner→FYCO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ATM →	-0.548	-2.991	.006	.036	3	4
COAD	ASNS →	+0.622	+3.008	.002	.019	3	3
UCEC	eEF2 →	+0.295	+1.584	.001	.007	3	3
COAD	p70-S6K_pT389 →	-0.230	-2.991	.048	.036	3	2
UCEC	eIF4E →	+0.161	+3.013	.003	<.001	3	2
UCEC	A-Raf_pS299 →	-0.080	-1.125	.009	.029	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 59 associations by consensus.

ATM by FYCO1 expression — COAD

Explore this box plot interactively →