FYCO1

Across TCGA cell cohorts, FYCO1 mutation is significantly associated with the RNA expression of many other genes, with 672 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FYCO1-associated genes across cancer lineages are PRAMEF33, OTC, and JOSD1. Each is linked with FYCO1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FYCO1-to-partner and partner-to-FYCO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRAMEF33 grouped by FYCO1-low versus FYCO1-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FYCO1→partner) and Y-score (partner→FYCO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PRAMEF33 →	+0.649	+5.029	<.001	.006	3	2
CNS	OTC →	+0.062	+2.771	<.001	.003	3	2
LARGE_INTESTINE	JOSD1 →	+0.596	+3.321	<.001	.003	3	2
LARGE_INTESTINE	SMC3 →	+0.563	+2.628	<.001	.002	3	2
LARGE_INTESTINE	TRIM37 →	+0.638	+3.409	.001	<.001	3	2
LARGE_INTESTINE	UBE2D3 →	+0.531	+3.389	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 672 associations by consensus.

PRAMEF33 by FYCO1 expression — LUNG_SCLC

Explore this box plot interactively →