FYB1

Across TCGA cell cohorts, FYB1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,808 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible FYB1-associated GO terms across cancer lineages are Small GTPase-mediated signal transduction, Negative regulation of transforming growth factor beta production, and Regulation of cytokine-mediated signaling pathway. Each is linked with FYB1 in more than 7 cancer types. Because this analysis shows association rather than direction, both FYB1-to-partner and partner-to-FYB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Small GTPase-mediated signal transduction grouped by FYB1-low versus FYB1-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FYB1→partner) and Y-score (partner→FYB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Small GTPase-mediated signal transduction →	+0.068	+1.814	<.001	<.001	3	8
BREAST	Negative regulation of transforming growth factor beta production →	+0.276	+1.486	<.001	.005	3	7
UPPER_AERODIGESTIVE_TRACT	Regulation of cytokine-mediated signaling pathway →	+0.080	+2.729	.002	<.001	3	7
BREAST	Cell-substrate junction organization →	+0.108	+0.947	<.001	.002	3	7
UPPER_AERODIGESTIVE_TRACT	Response to unfolded protein →	+0.092	+2.822	<.001	<.001	3	7
URINARY_TRACT	Regulation of fever generation →	+0.832	+1.768	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,808 associations by consensus.

Small GTPase-mediated signal transduction by FYB1 expression — PANCREAS

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