FXYD6

Across TCGA patient cohorts, FXYD6 mutation is significantly associated with the RNA expression of many other genes, with 1,950 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FXYD6-associated genes across cancer lineages are CISD3, OR5H7P, and DUTP3. Each is linked with FXYD6 in more than 1 cancer types. Because this analysis shows association rather than direction, both FXYD6-to-partner and partner-to-FXYD6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CISD3 grouped by FXYD6-low versus FXYD6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FXYD6→partner) and Y-score (partner→FXYD6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CISD3 →	+0.538	+3.732	.002	<.001	3	2
SKCM	OR5H7P →	+0.021	+3.993	.003	.008	3	2
SKCM	DUTP3 →	+0.058	+3.993	.001	.008	3	2
SKCM	MTCO1P52 →	+0.025	+4.485	<.001	.004	3	2
UCEC	TMEM138 →	+0.294	+3.258	.001	<.001	3	2
UCEC	MED8 →	+0.328	+3.290	.003	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,950 associations by consensus.

CISD3 by FXYD6 expression — UCEC

Explore this box plot interactively →