FXYD5

Across TCGA patient cohorts, FXYD5 protein abundance is significantly associated with the RNA expression of many other genes, with 9,317 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible FXYD5-associated genes across cancer lineages are PLD2, KCTD11, and ZSCAN12. Each is linked with FXYD5 in more than 4 cancer types. Because this analysis shows association rather than direction, both FXYD5-to-partner and partner-to-FXYD5 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, FXYD5 versus PLD2 in HNSC, with a Pearson correlation of 0.51.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FXYD5→partner) and Y-score (partner→FXYD5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PLD2 →	+0.758	+0.461	<.001	<.001	3	5
LSCC	KCTD11 →	+0.824	+0.215	<.001	<.001	3	5
HNSC	ZSCAN12 →	-0.709	-0.424	.001	<.001	3	4
BRCA	MINK1 →	+0.618	+0.209	<.001	.007	3	4
OV	VRK1 →	-0.576	-0.265	<.001	.007	3	3
OV	E2F3 →	-0.645	-0.283	<.001	.003	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,317 associations by consensus.

FXYD5 vs PLD2 — HNSC

Explore this scatter interactively →