FXYD5

Across TCGA patient cohorts, FXYD5 mutation is significantly associated with the RNA expression of many other genes, with 1,621 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FXYD5-associated genes across cancer lineages are TRIM60, SPANXN2, and MIR6766. Each is linked with FXYD5 in more than 2 cancer types. Because this analysis shows association rather than direction, both FXYD5-to-partner and partner-to-FXYD5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRIM60 grouped by FXYD5-low versus FXYD5-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FXYD5→partner) and Y-score (partner→FXYD5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	TRIM60 →	+0.259	+4.157	<.001	.002	3	3
BLCA	SPANXN2 →	+0.125	+6.814	<.001	<.001	3	2
BLCA	MIR6766 →	+0.610	+6.018	<.001	.002	3	2
BRCA	RPL23AP45 →	+0.127	+5.096	<.001	.008	3	2
HNSC	RNA5SP164 →	+0.373	+7.954	<.001	.008	3	2
UCEC	HSPE1P19 →	+0.153	+2.124	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,621 associations by consensus.

TRIM60 by FXYD5 expression — LUAD

Explore this box plot interactively →