FXYD5

Across TCGA patient cohorts, FXYD5 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FXYD5-associated genes across cancer lineages are EGFR_pY1068, FOXO3a_pS318_S321, and ACC1. Each is linked with FXYD5 in more than 1 cancer types. Because this analysis shows association rather than direction, both FXYD5-to-partner and partner-to-FXYD5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by FXYD5-low versus FXYD5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FXYD5→partner) and Y-score (partner→FXYD5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.233	-2.459	.033	.019	3	1
UCEC	FOXO3a_pS318_S321 →	-0.114	-2.115	.037	.019	3	1
UCEC	ACC1 →	+0.370	+2.115	.019	.019	3	1
UCEC	INPP4B →	-0.364	-2.794	.009	.003	3	1
UCEC	Ku80 →	+0.340	+3.469	<.001	.002	3	1
UCEC	MEK1 →	+0.589	+3.700	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

EGFR_pY1068 by FXYD5 expression — UCEC

Explore this box plot interactively →