FXYD3

Across TCGA patient cohorts, FXYD3 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FXYD3-associated genes across cancer lineages are ERK2, ACC1, and p70-S6K_pT389. Each is linked with FXYD3 in more than 1 cancer types. Because this analysis shows association rather than direction, both FXYD3-to-partner and partner-to-FXYD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by FXYD3-low versus FXYD3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FXYD3→partner) and Y-score (partner→FXYD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.209	+2.000	.016	.032	3	1
UCEC	ACC1 →	+0.356	+2.820	.030	.035	3	1
UCEC	p70-S6K_pT389 →	-0.211	-2.000	.013	.032	3	1
UCEC	Annexin-1 →	+0.572	+3.019	.016	.019	3	1
UCEC	Shc_pY317 →	-0.175	-2.700	.010	.006	3	1
UCEC	14-3-3_beta →	-0.125	-3.301	.005	.010	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

ERK2 by FXYD3 expression — UCEC

Explore this box plot interactively →