FXYD3

Across TCGA cell cohorts, FXYD3 protein abundance is significantly associated with the go_rna of many other GO terms, with 454 significant associations in total. OESOPHAGUS shows the largest number of these associations.

The most reproducible FXYD3-associated GO terms across cancer lineages are Negative regulation of dopaminergic neuron differentiation, Stress fiber assembly, and Contractile actin filament bundle assembly. Each is linked with FXYD3 in more than 2 cancer types. Because this analysis shows association rather than direction, both FXYD3-to-partner and partner-to-FXYD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of dopaminergic neuron differentiation grouped by FXYD3-low versus FXYD3-high in SKIN.

protein abundance associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FXYD3→partner) and Y-score (partner→FXYD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Negative regulation of dopaminergic neuron differentiation →	-0.153	-2.203	.002	<.001	3	3
LUNG_NSCLC_LUAD	Stress fiber assembly →	-0.110	-2.710	.005	.002	3	3
LUNG_NSCLC_LUAD	Contractile actin filament bundle assembly →	-0.110	-2.710	.005	.002	3	3
LUNG_SCLC	Mitotic DNA replication checkpoint signaling →	-0.249	-4.350	.004	.004	3	3
OESOPHAGUS	Neuromuscular process controlling balance →	-0.102	-1.878	.002	.001	3	3
LARGE_INTESTINE	Transposable element silencing →	+0.118	+1.863	.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 454 associations by consensus.

Negative regulation of dopaminergic neuron differentiation by FXYD3 expression — SKIN

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