FXYD2

Across TCGA patient cohorts, FXYD2 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible FXYD2-associated genes across cancer lineages are OR2BH1P, SRIP2, and ZBTB45P2. Each is linked with FXYD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both FXYD2-to-partner and partner-to-FXYD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2BH1P grouped by FXYD2-low versus FXYD2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FXYD2→partner) and Y-score (partner→FXYD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	OR2BH1P →	+0.059	+7.810	<.001	<.001	3	1
SKCM	SRIP2 →	+0.254	+5.680	<.001	.003	3	1
SKCM	ZBTB45P2 →	+0.030	+5.292	.002	.006	3	1
SKCM	LINC01005 →	+0.086	+5.867	<.001	.003	3	1
SKCM	HMGB1P22 →	+0.358	+5.037	<.001	.009	3	1
SKCM	PSMB7P1 →	+0.093	+6.469	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

OR2BH1P by FXYD2 expression — SKCM

Explore this box plot interactively →