FXYD1

Across TCGA pan-cancer cohorts, FXYD1 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated FXYD1 data layer compared with 4 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher FXYD1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated FXYD1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and UCS show a favorable association.

KIRP, LUAD, and UCS are the cancer types where FXYD1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	All	0.884	0.974	<.001	71	view →
LUAD	OS	Tertile	II,III,IV	0.854	0.626	.003	48	view →
UCS	DFS	Median	II,III,IV	0.543	0.145	.001	36	view →
SARC	DFS	Median	All	0.588	0.438	.001	26	view →
LGG	OS	Quartile	All	0.695	0.838	.002	26	view →
KICH	OS	Quartile	III,IV	0.125	0.697	.008	21	view →
UVM	OS	Quartile	II,III,IV	0.858	0.533	.003	19	view →
THCA	DFS	Median	IV	0.918	0.624	.001	19	view →
STAD	OS	Tertile	All	0.519	0.631	.020	17	view →
SCLC	OS	Median	II,III,IV	0.462	1.000	.005	15	view →
GBM	OS	Median	All	0.200	0.335	.005	15	view →
OV	DFS	Median	III,IV	0.131	0.180	.028	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

FXYD1–KIRP (OS)

Open the KIRP breakdown →