FXR2

Across TCGA cell cohorts, FXR2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,573 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible FXR2-associated GO terms across cancer lineages are Regulation of translation at synapse, modulating synaptic transmission, Regulation of translation at presynapse, and RNA localization. Each is linked with FXR2 in more than 19 cancer types. Because this analysis shows association rather than direction, both FXR2-to-partner and partner-to-FXR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of translation at synapse, modulating synaptic transmission grouped by FXR2-low versus FXR2-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FXR2→partner) and Y-score (partner→FXR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Regulation of translation at synapse, modulating synaptic transmission →	+0.163	+1.361	<.001	<.001	3	20
LUNG_NSCLC_LUSC	Regulation of translation at presynapse →	+0.188	+1.457	<.001	<.001	3	17
OESOPHAGUS	RNA localization →	+0.085	+0.619	<.001	<.001	3	17
LUNG_NSCLC_LUSC	Regulation of translation at presynapse, modulating synaptic transmission →	+0.188	+1.457	<.001	<.001	3	17
LUNG_NSCLC_LUSC	Regulation of translation at synapse →	+0.160	+1.235	<.001	<.001	3	16
LARGE_INTESTINE	Regulation of autophagosome maturation →	+0.084	+0.882	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,573 associations by consensus.

Regulation of translation at synapse, modulating synaptic transmission by FXR2 expression — LUNG_NSCLC_LUSC

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