FXR1

Across TCGA pan-cancer cohorts, FXR1 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated FXR1 data layer compared with 25 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher FXR1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated FXR1 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

BLCA, UCEC, and SKCM are the cancer types where FXR1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Median	III,IV	0.236	0.660	<.001	36	view →
UCEC	DFS	Median	All	0.976	0.602	<.001	36	view →
SKCM	DFS	Median	All	0.087	0.739	<.001	18	view →
COAD	OS	Median	II,III,IV	0.111	0.851	<.001	8	view →
HNSC	OS	Median	II,III,IV	0.212	0.600	.042	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

FXR1–BLCA (OS)

Open the BLCA breakdown →