FXR1

Across TCGA patient cohorts, FXR1 mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FXR1-associated genes across cancer lineages are Cyclin-E2, p38-MAPK_pT180_Y182, and ASNS. Each is linked with FXR1 in more than 2 cancer types. Because this analysis shows association rather than direction, both FXR1-to-partner and partner-to-FXR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-E2 grouped by FXR1-low versus FXR1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FXR1→partner) and Y-score (partner→FXR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-E2 →	+0.103	+1.241	.037	.015	3	3
UCEC	p38-MAPK_pT180_Y182 →	-0.387	-1.807	.003	.003	3	2
UCEC	ASNS →	+0.489	+2.247	<.001	.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.400	+1.242	.022	.020	3	2
UCEC	eEF2 →	+0.227	+1.807	.031	.024	3	1
UCEC	eIF4E →	+0.124	+1.999	.046	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

Cyclin-E2 by FXR1 expression — UCEC

Explore this box plot interactively →