FXR1

Across TCGA cell cohorts, FXR1 mutation is significantly associated with the RNA expression of many other genes, with 296 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FXR1-associated genes across cancer lineages are MS4A6E, BEX5, and GSTA3. Each is linked with FXR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FXR1-to-partner and partner-to-FXR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MS4A6E grouped by FXR1-low versus FXR1-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FXR1→partner) and Y-score (partner→FXR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	MS4A6E →	+0.050	+4.906	<.001	.006	3	2
LARGE_INTESTINE	BEX5 →	+1.529	+2.386	<.001	.007	3	2
PANCREAS	GSTA3 →	+0.025	+5.000	<.001	.006	3	1
PANCREAS	OR4N4 →	+0.035	+5.000	<.001	.006	3	1
OESOPHAGUS	BANF2 →	+0.146	+4.906	<.001	.006	3	1
OESOPHAGUS	RXFP3 →	+0.006	+4.906	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 296 associations by consensus.

MS4A6E by FXR1 expression — OESOPHAGUS

Explore this box plot interactively →