FXN

Across TCGA patient cohorts, FXN RNA expression is significantly associated with the protein abundance of many other proteins, with 16,133 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible FXN-associated proteins across cancer lineages are ANP32B, RPRD2, and SMARCA2. Each is linked with FXN in more than 5 cancer types. Because this analysis shows association rather than direction, both FXN-to-partner and partner-to-FXN results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, FXN versus ANP32B in BRCA, with a Pearson correlation of 0.43.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (FXN→partner) and Y-score (partner→FXN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ANP32B →	+0.364	+0.387	.001	<.001	3	6
BRCA	RPRD2 →	+0.299	+0.394	<.001	<.001	3	6
HNSC	SMARCA2 →	+0.323	+0.433	<.001	.004	3	6
COAD	EHMT1 →	+0.366	+0.533	.003	<.001	3	6
LSCC	SPIN1 →	+0.329	+0.396	<.001	<.001	3	5
LSCC	SSB →	+0.257	+0.292	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,133 associations by consensus.

FXN vs ANP32B — BRCA

Explore this scatter interactively →