FXN

Across TCGA patient cohorts, FXN protein abundance is significantly associated with the RNA expression of many other genes, with 12,280 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible FXN-associated genes across cancer lineages are LOX, P4HA3, and MXRA8. Each is linked with FXN in more than 5 cancer types. Because this analysis shows association rather than direction, both FXN-to-partner and partner-to-FXN results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, FXN versus LOX in OV, with a Pearson correlation of -0.42.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FXN→partner) and Y-score (partner→FXN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	LOX →	-1.258	-0.388	.003	.003	3	5
OV	P4HA3 →	-0.745	-0.429	.006	<.001	3	5
OV	MXRA8 →	-1.253	-0.364	.001	.005	3	5
COAD	CDC42 →	-0.385	-0.185	.007	.007	2	6
COAD	DSE →	-0.651	-0.229	<.001	<.001	3	4
OV	DCN →	-1.572	-0.540	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,280 associations by consensus.

FXN vs LOX — OV

Explore this scatter interactively →