FXN

Across TCGA patient cohorts, FXN mutation is significantly associated with the RNA expression of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FXN-associated genes across cancer lineages are COX6B1P2, RN7SL299P, and RNA5SP414. Each is linked with FXN in more than 1 cancer types. Because this analysis shows association rather than direction, both FXN-to-partner and partner-to-FXN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, COX6B1P2 grouped by FXN-low versus FXN-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FXN→partner) and Y-score (partner→FXN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	COX6B1P2 →	+0.433	+5.292	<.001	.006	3	1
SKCM	RN7SL299P →	+0.174	+6.469	<.001	.001	3	1
UCEC	RNA5SP414 →	+0.696	+2.933	<.001	.006	3	1
UCEC	STMN1P1 →	+0.533	+3.330	.002	.009	3	1
UCEC	ATP6V1E1P2 →	+0.239	+2.755	<.001	.009	3	1
SKCM	RNU6-973P →	+0.376	+4.979	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

COX6B1P2 by FXN expression — SKCM

Explore this box plot interactively →