FXN

Across TCGA patient cohorts, FXN mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FXN-associated genes across cancer lineages are C-Raf, IGFBP2, and Shc_pY317. Each is linked with FXN in more than 1 cancer types. Because this analysis shows association rather than direction, both FXN-to-partner and partner-to-FXN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by FXN-low versus FXN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FXN→partner) and Y-score (partner→FXN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C-Raf →	+0.229	+3.000	.005	.037	3	1
UCEC	IGFBP2 →	-1.248	-3.000	<.001	.037	1	1
UCEC	Shc_pY317 →	-0.243	-3.000	.005	.037	1	1
UCEC	VHL →	-1.339	-3.000	<.001	.037	1	1
UCEC	Caspase-8 →	-0.358	-3.000	.013	.037	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

C-Raf by FXN expression — UCEC

Explore this box plot interactively →