FXN

Across TCGA cell cohorts, FXN RNA expression is significantly associated with the go_rna of many other GO terms, with 4,778 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible FXN-associated GO terms across cancer lineages are [4Fe-4S] cluster assembly, [2Fe-2S] cluster assembly, and Endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Each is linked with FXN in more than 19 cancer types. Because this analysis shows association rather than direction, both FXN-to-partner and partner-to-FXN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, [4Fe-4S] cluster assembly grouped by FXN-low versus FXN-high in BLOOD_Myeloma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FXN→partner) and Y-score (partner→FXN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	[4Fe-4S] cluster assembly →	+0.207	+1.296	<.001	<.001	3	20
LUNG_NSCLC_LUSC	[2Fe-2S] cluster assembly →	+0.128	+0.753	<.001	.001	3	19
UPPER_AERODIGESTIVE_TRACT	Endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.151	+0.827	<.001	<.001	3	16
BLOOD_Myeloma	Maturation of 5.8S rRNA →	+0.116	+0.971	<.001	<.001	3	15
SOFT_TISSUE	Maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.102	+0.808	<.001	<.001	3	15
LUNG_SCLC	rRNA processing →	+0.122	+1.029	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,778 associations by consensus.

[4Fe-4S] cluster assembly by FXN expression — BLOOD_Myeloma

Explore this box plot interactively →