FUT7

Across TCGA patient cohorts, FUT7 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FUT7-associated genes across cancer lineages are A-Raf_pS299, MEK1, and p62 Lck ligand. Each is linked with FUT7 in more than 1 cancer types. Because this analysis shows association rather than direction, both FUT7-to-partner and partner-to-FUT7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by FUT7-low versus FUT7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FUT7→partner) and Y-score (partner→FUT7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.126	-3.169	.029	.019	3	1
UCEC	MEK1 →	+0.401	+3.000	.023	.036	3	1
UCEC	p62 Lck ligand →	+0.564	+3.331	<.001	.005	3	1
UCEC	Rab25 →	-0.336	-2.999	.036	.035	3	1
UCEC	Shc_pY317 →	-0.167	-3.169	.022	.019	3	1
UCEC	VEGFR2 →	+0.466	+2.472	.001	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

A-Raf_pS299 by FUT7 expression — UCEC

Explore this box plot interactively →