FUT6

Across TCGA cell cohorts, FUT6 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible FUT6-associated genes across cancer lineages are VWC2, COX6A2, and ADH1B. Each is linked with FUT6 in more than 1 cancer types. Because this analysis shows association rather than direction, both FUT6-to-partner and partner-to-FUT6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VWC2 grouped by FUT6-low versus FUT6-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FUT6→partner) and Y-score (partner→FUT6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	VWC2 →	+0.009	+4.415	<.001	.007	3	2
BLOOD_Myeloma	COX6A2 →	+0.773	+3.906	.003	.009	3	1
BLOOD_Myeloma	ADH1B →	+0.069	+4.285	<.001	.003	3	1
LARGE_INTESTINE	IL17F →	+0.045	+4.112	.003	<.001	3	1
LARGE_INTESTINE	GZMK →	+0.008	+3.700	<.001	.009	3	1
LARGE_INTESTINE	OR2S2 →	+0.109	+3.217	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

VWC2 by FUT6 expression — SKIN

Explore this box plot interactively →