Across TCGA pan-cancer cohorts, FUT4 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated FUT4 data layer compared with 23 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in lymphoid neoplasm diffuse large b-cell lymphoma (DLBC), where higher FUT4 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated FUT4 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

DLBC, ESCA, and PRAD are the cancer types where FUT4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
DLBC	OS	Median	All	0.053	0.936	<.001	12	view →
ESCA	OS	Median	All	0.198	0.872	.003	12	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
READ	DFS	Median	II,III,IV	0.111	0.793	.001	3	view →
UCEC	DFS	Median	All	0.956	0.828	.032	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: FUT4 tumor-vs-normal RNA expression · all FUT4 data types