Across TCGA pan-cancer cohorts, FUT4 mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of FUT4’s most consistent transcriptional readouts.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where FUT4 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types FUT4 is over-expressed in tumor, although a few such as LUAD show the opposite, repressed pattern.

PDAC, LUAD, and LSCC are the cancer types where FUT4 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FUT4 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
PDAC	Male	IV	+0.995	<.001	9	view →
LUAD	All	All	−0.777	<.001	6	view →
LSCC	Male	II,III,IV	+0.721	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: FUT4 RNA expression & survival · all FUT4 data types