FUT2

Across TCGA patient cohorts, FUT2 mutation is significantly associated with the RNA expression of many other genes, with 2,504 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FUT2-associated genes across cancer lineages are DGAT2, HMG20B, and DCPS. Each is linked with FUT2 in more than 2 cancer types. Because this analysis shows association rather than direction, both FUT2-to-partner and partner-to-FUT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DGAT2 grouped by FUT2-low versus FUT2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FUT2→partner) and Y-score (partner→FUT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DGAT2 →	-0.642	-3.735	.001	<.001	3	3
UCEC	HMG20B →	+0.490	+3.828	<.001	<.001	3	3
UCEC	DCPS →	+0.431	+1.936	.003	.003	3	3
UCEC	IER3IP1 →	+0.450	+3.716	.002	<.001	3	3
UCEC	BAG3 →	+0.625	+3.087	<.001	<.001	3	2
UCEC	JAKMIP1 →	+0.452	+3.700	.005	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,504 associations by consensus.

DGAT2 by FUT2 expression — UCEC

Explore this box plot interactively →