FUT2

Across TCGA patient cohorts, FUT2 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FUT2-associated genes across cancer lineages are LKB1, Rab25, and Annexin-1. Each is linked with FUT2 in more than 1 cancer types. Because this analysis shows association rather than direction, both FUT2-to-partner and partner-to-FUT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LKB1 grouped by FUT2-low versus FUT2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FUT2→partner) and Y-score (partner→FUT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	LKB1 →	+0.102	+3.178	.035	.010	3	2
COAD	Rab25 →	-0.354	-3.000	.006	.035	3	2
UCEC	Annexin-1 →	+0.559	+1.678	.005	.023	3	2
UCEC	S6_pS240_S244 →	+0.369	+3.459	.017	.005	3	2
UCEC	Caspase-7-cleavedD198 →	+0.627	+3.479	.005	.002	3	2
COAD	Lck →	+0.465	+3.195	.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

LKB1 by FUT2 expression — COAD

Explore this box plot interactively →