FUS

Across TCGA patient cohorts, FUS RNA expression is significantly associated with the protein abundance of many other proteins, with 11,845 significant associations in total. GBM shows the largest number of these associations.

The most reproducible FUS-associated proteins across cancer lineages are TRIM28, SF3B3, and SREK1. Each is linked with FUS in more than 5 cancer types. Because this analysis shows association rather than direction, both FUS-to-partner and partner-to-FUS results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, FUS versus TRIM28 in GBM, with a Pearson correlation of 0.37.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (FUS→partner) and Y-score (partner→FUS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TRIM28 →	+0.349	+0.542	.002	<.001	3	6
LSCC	SF3B3 →	+0.241	+0.610	<.001	<.001	3	6
GBM	SREK1 →	+0.337	+0.552	<.001	<.001	3	5
GBM	NONO →	+0.246	+0.577	<.001	<.001	3	5
GBM	POLR2E →	+0.250	+0.562	<.001	<.001	3	5
COAD	USP7 →	+0.256	+0.601	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,845 associations by consensus.

FUS vs TRIM28 — GBM

Explore this scatter interactively →