FUS

Across TCGA patient cohorts, FUS protein abundance is significantly associated with the RNA expression of many other genes, with 19,125 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible FUS-associated genes across cancer lineages are LYSMD1, DPP4, and ZNF48. Each is linked with FUS in more than 7 cancer types. Because this analysis shows association rather than direction, both FUS-to-partner and partner-to-FUS results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, FUS versus LYSMD1 in LSCC, with a Pearson correlation of 0.62.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FUS→partner) and Y-score (partner→FUS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	LYSMD1 →	+0.618	+0.432	<.001	<.001	3	8
UCEC	DPP4 →	-2.111	-0.633	<.001	<.001	3	8
LSCC	ZNF48 →	+0.630	+0.399	<.001	<.001	3	7
GBM	MEX3A →	+1.258	+0.403	<.001	<.001	3	7
LSCC	KIF22 →	+0.897	+0.528	<.001	<.001	3	7
HNSC	POLR3C →	+0.661	+0.365	.001	.004	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,125 associations by consensus.

FUS vs LYSMD1 — LSCC

Explore this scatter interactively →