FUS

Across TCGA cell cohorts, FUS RNA expression is significantly associated with the go_rna of many other GO terms, with 4,831 significant associations in total. BONE shows the largest number of these associations.

The most reproducible FUS-associated GO terms across cancer lineages are DNA-templated DNA replication, Regulation of double-strand break repair, and DNA-templated DNA replication maintenance of fidelity. Each is linked with FUS in more than 19 cancer types. Because this analysis shows association rather than direction, both FUS-to-partner and partner-to-FUS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA-templated DNA replication grouped by FUS-low versus FUS-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FUS→partner) and Y-score (partner→FUS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	DNA-templated DNA replication →	+0.153	+0.933	<.001	<.001	3	19
OVARY	Regulation of double-strand break repair →	+0.076	+0.740	<.001	<.001	2	20
BONE	DNA-templated DNA replication maintenance of fidelity →	+0.149	+1.112	<.001	<.001	3	19
OESOPHAGUS	DNA replication →	+0.136	+0.787	<.001	.003	3	19
BLOOD_Myeloma	Interstrand cross-link repair →	+0.107	+1.178	<.001	<.001	3	19
BONE	Regulation of double-strand break repair via homologous recombination →	+0.134	+1.084	<.001	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,831 associations by consensus.

DNA-templated DNA replication by FUS expression — BONE

Explore this box plot interactively →