Across TCGA pan-cancer cohorts, FUNDC2P3 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of FUNDC2P3’s most consistent transcriptional readouts.
The strongest signal is observed in thyroid carcinoma (THCA), where FUNDC2P3 RNA is repressed in tumor relative to normal tissue. In most cancer types FUNDC2P3 is over-expressed in tumor, although a few such as THCA and KIRP show the opposite, repressed pattern.
THCA and KIRP are the cancer types where FUNDC2P3 tumor–normal differential expression is most reproducible.