FUNDC2

Across TCGA patient cohorts, FUNDC2 mutation is significantly associated with the RNA expression of many other genes, with 552 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FUNDC2-associated genes across cancer lineages are LINC00583, RN7SKP245, and MTCYBP14. Each is linked with FUNDC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both FUNDC2-to-partner and partner-to-FUNDC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC00583 grouped by FUNDC2-low versus FUNDC2-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FUNDC2→partner) and Y-score (partner→FUNDC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	LINC00583 →	+0.111	+7.333	<.001	<.001	3	2
COAD	RN7SKP245 →	+0.366	+5.693	.007	.003	3	2
COAD	MTCYBP14 →	+0.237	+6.392	<.001	.001	3	2
UCEC	LSP1P1 →	+0.436	+2.436	<.001	.003	3	2
UCEC	OR4B1 →	+0.071	+3.312	<.001	.001	3	2
UCEC	RNA5SP408 →	+0.318	+2.727	.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 552 associations by consensus.

LINC00583 by FUNDC2 expression — LUAD

Explore this box plot interactively →