FUNDC2

Across TCGA patient cohorts, FUNDC2 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FUNDC2-associated genes across cancer lineages are MYH11, SF2, and Bak. Each is linked with FUNDC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both FUNDC2-to-partner and partner-to-FUNDC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYH11 grouped by FUNDC2-low versus FUNDC2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FUNDC2→partner) and Y-score (partner→FUNDC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MYH11 →	-1.330	-2.459	.016	.020	3	1
UCEC	SF2 →	+0.111	+3.026	.035	.018	3	1
UCEC	Bak →	+0.269	+3.321	.026	.010	3	1
UCEC	Caspase-8 →	-0.282	-3.143	.020	.018	3	1
UCEC	c-Kit →	-0.249	-3.584	.026	.002	3	1
UCEC	JNK2 →	+0.193	+2.817	.044	.036	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

MYH11 by FUNDC2 expression — UCEC

Explore this box plot interactively →