FUNDC2

Across TCGA cell cohorts, FUNDC2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,020 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible FUNDC2-associated GO terms across cancer lineages are Negative regulation of synaptic vesicle exocytosis, snRNA pseudouridine synthesis, and Regulation of lipid transport. Each is linked with FUNDC2 in more than 11 cancer types. Because this analysis shows association rather than direction, both FUNDC2-to-partner and partner-to-FUNDC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of synaptic vesicle exocytosis grouped by FUNDC2-low versus FUNDC2-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FUNDC2→partner) and Y-score (partner→FUNDC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Negative regulation of synaptic vesicle exocytosis →	+0.133	+0.627	.001	.001	3	12
BLOOD_Lymphoma	snRNA pseudouridine synthesis →	+0.051	+0.656	.002	<.001	3	10
SOFT_TISSUE	Regulation of lipid transport →	-0.056	-0.678	.003	<.001	3	9
OVARY	Spliceosomal tri-snRNP complex assembly →	+0.094	+0.744	<.001	<.001	3	9
SOFT_TISSUE	Transcription initiation at RNA polymerase II promoter →	+0.053	+0.705	.002	<.001	3	8
UPPER_AERODIGESTIVE_TRACT	Positive regulation of telomerase RNA localization to Cajal body →	+0.067	+0.513	.002	.009	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,020 associations by consensus.

Negative regulation of synaptic vesicle exocytosis by FUNDC2 expression — OVARY

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