FUCA1

Across TCGA patient cohorts, FUCA1 mutation is significantly associated with the total protein of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FUCA1-associated genes across cancer lineages are EGFR_pY1173, MIG-6, and PDK1_pS241. Each is linked with FUCA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FUCA1-to-partner and partner-to-FUCA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1173 grouped by FUCA1-low versus FUCA1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FUCA1→partner) and Y-score (partner→FUCA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1173 →	+0.100	+2.833	.041	.035	3	1
UCEC	MIG-6 →	+0.134	+2.820	.027	.036	3	1
UCEC	PDK1_pS241 →	+0.264	+2.820	.011	.036	1	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

EGFR_pY1173 by FUCA1 expression — UCEC

Explore this box plot interactively →